Ingredients: Alphasize(R) 50 P (Alpha-Glyceryl Phosphoryl Choline (A-GPC)), Rhodiola Rosea Extract, Lion’s Mane Mushroom (Hericium Erinaceus) 10:1, Panax Ginseng (10% Ginsenosides), L-Tyrosine, Phosphatidylserine, PQQ (Pyrroloquinoline Quinone Disodium Salt), Vitamin B1 (Thiamin), Vitamin B12 (Cyanocobalamin), Green Coffee Bean (Coffea Arabica), L-Theanine
1. ALPHASIZE(R) 50 P (ALPHA-GLYCERYL PHOSPHORYL CHOLINE (A-GPC))
Alpha-GPC is a cholinergic compound that is known to be a precursor to acetylcholine and phosphatidylcholine in the body following ingestion. It is used for its properties promoting cognition and enhancement of power output in athletes. It has been shown to improve mind-to-muscle connection and cellular membranes, increase cognitive function and decrease the cognitive decline in individuals with cognitive impairments such as dementia. (1) (2)
2. RHODIOLA ROSEA EXTRACT
Rhodiola is one of the most potent adaptogens to have ever been studied. This herbal extract is considered to be an adaptogen as well as a cognitive enhancer. Rhodiola is fast-acting and has been shown to fight fatigue, support a positive mood, increase motivation, and improve physical and mental performance.
3. LION’S MANE MUSHROOM (HERICIUM ERINACEUS) 10:1
Hericium Erinaceus (Lion’s Mane) is a dietary mushroom that has been shown to significantly reduce the rate of cognitive decline in older people. (8) Lion’s Mane has shown to be a promising cognitive enhancer by increasing mRNA expression of nerve growth factors as well as decreasing anxiety, stress, and depressive symptoms. (9) (10) (11) This mushroom has even been shown to increase cognitive function in individuals with cognitive impairments such as dementia. (12)
4. PANAX GINSENG (10% GINSENOSIDES)
Panax Ginseng is an herb that is classified as a powerful adaptogen. Ginseng is most commonly known for combating fatigue, which can have energy-producing effects and improve cognitive performance. (13) Ginseng causes an increase in all three of the main antioxidant enzymes (SOD, glutathione peroxidase, and catalase) and has been shown to decrease biomarkers of muscle damage (creatine kinase) for 72 hours after exercise. (14) (15) Panax Ginseng also contains naturally occurring ginsenosides, which play a role in improving focus, sharpening memory, and supporting overall well-being. Ginseng promotes the release of nitric oxide, which opens blood vessels and improves blood flow to the brain and muscles.
L-Tyrosine is an amino acid used in producing neurotransmitters such as noradrenaline, epinephrine, and dopamine. It appears to reduce stress during exposure to acute stressors (which tend to deplete noradrenaline) and can help in the prevention of stress-induced memory deficits. The amino acid tyrosine, a catecholamine precursor, is known to improve cognitive performance in young adults, especially during periods of high environmental demands. Tyrosine administration might also affect catecholamine transmission in the aging brain, thereby improving cognitive function. (16) Supplementing with L-tyrosine converts it to L-dopa, which is the initial and rate-limiting step in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline—playing a central role in neurotransmission and hormonal actions. (17) The thyroid gland needs tyrosine to make the thyroxine hormone, and the skin needs it to make melanin. Having sufficient quantities of tyrosine in the brain promotes mental clarity in dealing with stress. Supplementation with tyrosine might, under operational circumstances characterized by psychosocial and physical stress, reduce the effects of stress and fatigue during cognitive task performance. (17)
Phosphatidylserine (PS) is an amino acid derivative compound that is fat-soluble and a universal building block for cell membranes in the brain, where it is found in large quantities and contributes to cognitive function. This phospholipid nutrient is present in all our cells and is especially concentrated in the brain’s nerve cells. PS helps improve attention and the ability to cope with stress. PS is the best-documented nutrient for improved recalling of words, names, faces, and events in people over 50. It has shown support against cognitive decline as well as the potential to improve memory lower cortisol levels in the elderly. (19) (20) PS supports the reduction of stress, resulting in an increase in attention. (21)
7. PQQ (PYRROLOQUINOLINE QUINONE DISODIUM SALT)
PQQ aids cellular energy production, mitochondrial health and defends the body against oxidative stress. (22) It has been found to be a potent enhancer of the nerve growth factor, stimulating nerve growth, creation, and discharge in neuron-supporting cells in the brain. PQQ is a strong neuroprotective compound that protects/improves cognition, memory, and attention in aging humans, thereby slowing age-related cognitive decline. (23) PQQ also stimulates the formation of new mitochondria and genes governing mitochondrial protection, reproduction, plasma C- reactive protein levels, and repair. (24) (25) When PQQ is taken together with coenzyme Q10, it can improve mental state and quality of life. PQQ has been shown to significantly decrease plasma C- reactive protein levels, which is responsible for inflammation in the body. (26) PQQ is also involved in physiological processes including redox modulation, cellular energy metabolism, mitochondrial biogenesis, and antioxidant potential. (25)
8. VITAMIN B1 (THIAMIN)
Thiamine, also known as Vitamin B1, plays a fundamental role in energy metabolism. (27) Benfotiamine, which is a relative of Thiamine (B1), appears to have a therapeutic role in pain reduction and diabetic complications (neuropathies and nephropathies) and has an absorption rate (bioavailability) that is approximately five times that of thiamine and 3.7 times higher than Thiamine Hydrochloride. (28). Befotiamine has also been shown to have antioxidant and anti-inflammatory properties while supporting physical and mental stimulation.
9. VITAMIN B12 (CYANOCOBALAMIN)
Vitamin B12, methylcobalamin, is a water-soluble essential vitamin that has a known role in our neurology. B12 is essential for DNA synthesis and cellular energy production. (29) B12 has shown to help prevent major birth defects, reduce macular degeneration, improve mood and symptoms of depression. Supplementation is particularly important for those at greater risk of deficiency such as older individuals and vegans.
10. GREEN COFFEE BEAN (COFFEA ARABICA)
Green coffee beans have a higher level of chlorogenic acid compared to regular, roasted coffee beans. Green coffee beans provide chlorogenic acid and act as an antioxidant, providing health and cognitive benefits. (30)
Theanine is an amino acid that is not commonly obtained from foods. Supplementing theanine can increase sleep quality and verbal fluency. Theanine helps reduce the perception of stress and slightly improves attention. (31) It also promotes relaxation without drowsiness, making it synergistic with caffeine. Theanine is structurally similar to glutamine and both neurotransmitters that are produced from it (GABA and glutamate) and is known to reach the brain and act on it following oral ingestion.